De Mossel 11a, 1723 HZ Noord-Scharwoude |
aUtoLoGoUs pLateLet ConCentrate
Healing Cascade
the body‘s response to injury is a very specific and well
documented series of steps collectively referred to as the
”Healing Cascade”. this cascade is comprised of several
distinct phases. the natural healing process requires a
systems approach that combines the use of Growth Factors
and stem Cells integrated into a Matrix to optimize bone/
tissue repair and regeneration. (Fig. 1)
the use of these bioactive cells to augment and accelerate
the natural healing process is considered by many to be a
“new frontier” of clinical treatment.
autologous platelet Concentrate (
) is a specific
concentration of platelets and plasma that can be directly
delivered to any surgical wound to create the conditions
to accelerate healing. (Fig. 2)
Growth Factors
the early stages of the healing cascade are primarily
mediated by platelets and the release of cellular growth
factors. (Fig. 3)
Platelet-Derived Growth Factor (PDGF):
•
initiates connective tissue healing
•
increases mitogenesis, angiogenesis, and
macrophage activation
Vascular Endothelial Growth Factor (VEGF):
•
possess potent angiogenic, mitogenic, and vascular
permeability enhancing activities
Transforming Growth Factor-ß (TGF-ß):
•
increases chemotaxis and
mitogenesis
•
stimulates deposition of collagen
Epidermal Growth Factor (EGF):
•
induces epithelial development
•
promotes angiogenesis
Chemomigration
as the wound continues to
mature, healing progresses
by attracting stem cells
from the periphery into the
affected area.
autologous platelet Concentrate (
) contains high
concentrations of growth factors within alpha-granule releasate.
this initiates a cascade that results in chemoattraction of
circulating stem cells promoting differentiation (proliferation),
to develop into mature tissues.
Scaffold
Growth Factors
Adult Stem Cell
Blood
Healing
Trinity
healing cascade
Natural healing
Time
PDGF-AB TGF-ß1 VEGF
EGF
100%
600%
100%
727%
100%
428%
100%
550%
Fig. 1
Fig. 3
Fig. 2
